Frequent COVID Boosters in Immunocompromised ‘May Be Causing More Harm Than Benefit’: New Review Suggests

Frequent administration of mRNA COVID-19 boosters may impair the immune system response in immune-compromised individuals, raising questions about whether giving multiple vaccine doses is more harmful than beneficial.

According to a narrative review published on Jan. 27 in Clinical and Experimental Medicine, repeated COVID-19 vaccination may increase the likelihood of experiencing SARS-CoV-2 infection and other pathologies. Additionally, receiving multiple doses may result in much higher levels of IgG4 antibodies and impair the activation of white blood cells that help protect the body from infections and cancer.

Immunoglobulins, or antibodies, are proteins made by specialized white blood cells called B cells. Although IgG4 antibodies have a protective effect up to a certain level, a growing body of evidence suggests that abnormally high levels from repeated vaccination may cause IgG4-related disease involving multiorgan inflammation, autoimmune diseases, rapid onset cancers, and autoimmune myocarditis.

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